The Singapore Human Mutation
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<< Gene or Locus List >>

KRAS
OMIM: *190070
Gene Name: v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

all members of ras family are converted to active oncogenes in naturally occuring tumours by point mutations in codons 12, 12 or 61

7 mutations/polymorphisms recorded....
[1] 34G>A : Paper 1
[2] 34G>T : Paper 1
[3] 35G>A : Paper 1
[4] 35G>C : Paper 1
[5] 35G>T : Paper 1
[6] 40G>T : Paper 1
[7] 41G>A : Paper 1


Mutation/Polymorphism (3): 35G>A
Related Disease: Colorectal Cancer
Sample Size/Sex: 68 samples (18 archival, 50 contemporary)
Sample Ethnic Group:


Frequency in Sample
Allele or Genotype No Cases/Control/Sample Type Race Sex Data
with Stated Mutation/Polymorphism na na 0 (0.0%)
with Stated Mutation/Polymorphism na na 7 (14.0%)
with Stated Mutation/Polymorphism na na 7 (10.3%)
without Stated Mutation/Polymorphism na na 18 (100.0%)
without Stated Mutation/Polymorphism na na 43 (86.0%)
without Stated Mutation/Polymorphism na na 61 (89.7%)

Reference (PUBMED Accession No.): 10496348
Br J Cancer 1999 Sep; 81(2):237-41. c-Ki-ras mutations in colorectal adenocarcinomas from a country with a rapidly changing colorectal cancer incidence. Tang WY, Elnatan J, Lee YS, Goh HS, Smith DR.


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