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<< Gene or Locus List >>

FGA
OMIM: *134830
Gene Name: fibrinogen alpha chain

encodes fibrinogen alpha chain; fibrinogen is an acute phase protein whose levels rise rapidly in response to infection, inflammation, injury or other trauma

3 mutations/polymorphisms recorded....
[1] 934A>G : Paper 1
[2] STR polymorphism : Paper 1
[3] TaqI polymorphism at 3’end; T1 or TaqI(-): 900bp digested fragment; T2 or TaqI(+): 100bp and 800bp fragments : Paper 1


Mutation/Polymorphism (3): TaqI polymorphism at 3’end; T1 or TaqI(-): 900bp digested fragment; T2 or TaqI(+): 100bp and 800bp fragments
Related Disease: Coronary Heart Disease
Sample Size/Sex: 400 (189 men and 211 women; 130 men are non-smokers; 59 men are smokers)
Sample Ethnic Group: Chinese

Allele or Genotype available
Allele 1 : T1
Allele 2 : T2


Frequency in Controls
Allele or Genotype No Cases/Control/Sample Type Race Sex Data
Allele 1 Control Chinese Female 0.602
Allele 2 Control Chinese Female 0.398
Allele 1 Control Chinese Male 0.540
Allele 2 Control Chinese Male 0.460
Allele 1 Control Chinese na 0.573
Allele 2 Control Chinese na 0.427
Allele 1 Control; Non-Smokers Chinese na 0.550
Allele 2 Control; Non-Smokers Chinese na 0.450
Allele 1 Control; Smokers Chinese na 0.517
Allele 2 Control; Smokers Chinese na 0.483
Genotype 1-1 Control Chinese Female 80 (37.9%)
Genotype 1-2 Control Chinese Female 94 (44.5%)
Genotype 2-2 Control Chinese Female 37 (17.6%)
Genotype 1-1 Control Chinese Male 55 (29.1%)
Genotype 1-2 Control Chinese Male 94 (49.7%)
Genotype 2-2 Control Chinese Male 40 (21.2%)
Genotype 1-1 Control Chinese na 135 (38.8%)
Genotype 1-2 Control Chinese na 188 (47.0%)
Genotype 2-2 Control Chinese na 77 (19.2%)
Genotype 1-1 Control; Non-Smokers Chinese na 39 (30.0%)
Genotype 1-2 Control; Non-Smokers Chinese na 65 (50.0%)
Genotype 2-2 Control; Non-Smokers Chinese na 26 (20.0%)
Genotype 1-1 Control; Smokers Chinese na 16 (27.1%)
Genotype 1-2 Control; Smokers Chinese na 29 (49.2%)
Genotype 2-2 Control; Smokers Chinese na 14 (23.7%)

Reference (PUBMED Accession No.): 11546832
J Med Genet. 2001 Sep;38(9):E31. Fibrinogen genotypes (alpha and beta) are associated with plasma fibrinogen levels in Chinese. Liu Y, Saha N, Heng CK, Hong S, Low PS.


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