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FGA
OMIM: *134830
Gene Name: fibrinogen alpha chain

encodes fibrinogen alpha chain; fibrinogen is an acute phase protein whose levels rise rapidly in response to infection, inflammation, injury or other trauma

3 mutations/polymorphisms recorded....
[1] 934A>G : Paper 1
[2] STR polymorphism : Paper 1
[3] TaqI polymorphism at 3’end; T1 or TaqI(-): 900bp digested fragment; T2 or TaqI(+): 100bp and 800bp fragments : Paper 1


Mutation/Polymorphism (1): 934A>G
Related Disease: Coronary Heart Disease
Sample Size/Sex: 402 (190 men and 212 women; 130 men are smokers; 60 men are non-smokers)
Sample Ethnic Group: Chinese

Allele or Genotype available
Allele 1 : T
Allele 2 : A


Frequency in Controls
Allele or Genotype No Cases/Control/Sample Type Race Sex Data
Allele 1 Control Chinese Female 0.592
Allele 2 Control Chinese Female 0.408
Allele 1 Control Chinese Male 0.539
Allele 2 Control Chinese Male 0.461
Allele 1 Control Chinese na 0.567
Allele 2 Control Chinese na 0.433
Allele 1 Control; Non-Smokers Chinese Male 0.55
Allele 2 Control; Non-Smokers Chinese Male 0.45
Allele 1 Control; Smokers Chinese Male 0.517
Allele 2 Control; Smokers Chinese Male 0.483
Genotype 1-1 Control Chinese Female 78 (36.8%)
Genotype 1-2 Control Chinese Female 95 (44.8%)
Genotype 2-2 Control Chinese Female 39 (18.4%)
Genotype 1-1 Control Chinese Male 54 (28.4%)
Genotype 1-2 Control Chinese Male 97 (57.1%)
Genotype 2-2 Control Chinese Male 39 (20.5%)
Genotype 1-1 Control Chinese na 132 (32.8%)
Genotype 1-2 Control Chinese na 192 (47.8%)
Genotype 2-2 Control Chinese na 78 (19.4%)
Genotype 1-1 Control; Non-Smokers Chinese Male 38 (29.2%)
Genotype 1-2 Control; Non-Smokers Chinese Male 67 (51.5%)
Genotype 2-2 Control; Non-Smokers Chinese Male 25 (19.3%)
Genotype 1-1 Control; Smokers Chinese Male 16 (26.7%)
Genotype 1-2 Control; Smokers Chinese Male 30 (50.0%)
Genotype 2-2 Control; Smokers Chinese Male 14 (23.3%)

Reference (PUBMED Accession No.): 11546832
J Med Genet. 2001 Sep;38(9):E31. Fibrinogen genotypes (alpha and beta) are associated with plasma fibrinogen levels in Chinese. Liu Y, Saha N, Heng CK, Hong S, Low PS.


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